We open with the guys – Sheldon, Leonard, Howard, and Raj – eating lunch in the cafeteria at work. Sheldon announces that he thinks he’s found a way to get young people interested in science – Physics Mad Libs! He asks the guys to help him fill out the mad lib, and then reads back an equation. He can barely get through it without breaking into hysterics. The rest of the guys are confused, but Sheldon is not swayed. The President of their department comes over to the table and tells Sheldon that he must take a vacation, since he hasn’t taken one in the entire time he’s been employed there. Sheldon seems perturbed – he doesn’t want to take a vacation. What will he do with himself? “Read,” he responds, “Relax? I hear Afghanistan is nice this time of year.”

The next day, Leonard is driving to work singing and dancing along to the music. Suddenly, Sheldon pops out of the back seat demanding that he stop singing. “What are you doing back there?!” demands Leonard. “Bleeding from the ears,” responds Sheldon. Rude! Sheldon then tells Leonard that he is going to sneak into work, and if anyone asks him what’s under the blanket, he should say it’s lobsters – that’s what Shaggy and Velma said when they needed to sneak Scooby in. When Sheldon has ducked back down, Leonard turns the car around. Sheldon informs him that he knows he turned around, as he has GPS on her phone.

Meanwhile, the girl are hanging out and Penny is congratulating Bernadette on talking Howard out of wanting their wedding invitations written in Kling-on. Turns out, the back of the invitation is in Kling-on, but Bernadette is hoping that everyone will think it’s Hebrew. Amy, however, is thrilled that she is going to be a maid of honor, getting to walk down the aisle on her big day… oh wait, doesn’t she mean Bernadette’s big day? “Someone is going to need an extra large veil,” quips Amy. Nope, I guess she did mean her [Amy's] big day.

While the guys are trying to convince Sheldon that he should go on vacation (Hawaii? Florida? Nope, all rejected.), Bernadette confides to the girls that she wants Howard to sign a pre-nuptial agreement. Later, Penny tells Leonard what Bernadette has confided in her, and makes him promise not to tell. Leonard is conflicted as to whether or not he should tell Howard. Raj advises him the same way he advises the men giving out roses on The Bachelor, “follow your heart.”

Sheldon decides that the best way to spend his vacation is to work in Amy’s lab. He’s insulted, however, when Amy asks him to do menial tasks, such as wash the beakers. He’s had a tamagotchi since 1998 and it’s still alive. Of course he knows Biology! He’s especially insulted when Amy sends him back to the sink with a beaker, saying it isn’t clean. When Sheldon argues, Amy tells him that the beaker used to contain a sample of encephalitis and if he’s so sure that it’s clean he should drink out of it. Sheldon heads back to the sink.

Leonard decides to tell Howard about the pre-nup, and Howard is clearly miffed. He isn’t sure what he should do (Raj advises to follow his heart, again), but reasons that it’s the practical and smart thing to do – after all, Bernadette makes more money than he does, and she’s just protecting her assets. And, come to think of it – he’s got assets to protect too. Rare comic books, a cemetery plot…

Once Sheldon has finished cleaning the beakers, he begins arguing with Amy again. She’s assigned him to count bacteria spores in a petri dish, which he finds demeaning. When she asks how it’s going, he snarkily (in typical Sheldon fashion) replies “Oh, the counting? In kindergarten I recited pi to the thousandth place. I think I got this.” He then promptly starts counting over, since he lost his place.  She says that she’s been training in the field of biology for 12 years, and he’s been in the lab for 3 hours – there’s no way he’s as qualified as she is. To prove her point, Amy allows Sheldon to help out. She’s got to cut the Locus Scurrilous out of a brain, and it’s the width of a single hair. Sheldon insists that he’s all set, as his hands shake uncontrollably.  Once he makes an incision, he asks if brains usually bleed a lot. Turns out, they don’t – but a human thumb does. Sheldon passes out.

Later, we meet Sheldon and Howard at the bar. Sheldon is there because he’s on vacation, obviously. (Pina Colada, extra everything – hold the rum.) Howard is mulling over the decision to sign Bernadette’s pre-nup. When Penny walks over (she’s working, after all), she tells Howard that he should sign anything Bernadette puts in front of him, since he is the luckiest guy in the world to end up with her, and Penny knows this – since she’s speaking from the position of being a female. She then gives Sheldon a hard time about passing out at the sight of blood. When he tries to defend himself by showing Penny the cut and saying it was a substantial amount of blood, he passes out again.

The next day, Sheldon goes back to Amy’s lab with his tail between his legs. He tells Amy that he wasn’t himself, as he lost a lot of blood. Amy points out that that isn’t an apology. Sheldon astutely comments that that is her opinion. Amy tells Sheldon she won’t allow him back in the lab until he apologizes. After trying to apologize on behalf of everything but himself (“I’m sorry you felt,” “I’m sorry my thumb,” “I’m sorry the soap”) he finally utters a quick, “sorry.” Amy forgives his previous behavior, and then directs him back to the sink to finish cleaning out beakers. Next year, Sheldon is going to Epcot.

Finally, we meet up with Bernadette and Howard, who are having a problem without ever having spoken to each other once during this episode (like a real relationship!). Howard tells Bernadette that he’s uncomfortable signing the pre-nup, and she tells him that it’s really her father who wants him to sign it. Howard says he’ll talk to Bernadette’s father about it, and she says that’s a good idea. She then warns Howard that her father still enjoys carrying around his gun, even though he’s been retired from the police force for some time, and throws in some tips and tricks for dealing with her father, including a litany of things for Howard to not bring up, such as the fact that he’s Jewish. Finally, she leaves Howard with the advice that if her father is yelling, he’s in good shape. But if he starts speaking really quietly, Howard should run – and not in a straight line, he should throw some zig-zags in there.